For an oocyte being Prepared for fertilization and development into an embryo, the correct set of genes needs to be turned on. Namekawa suspected this pre-programming on the oocyte genome happens in many levels — the first just one starting throughout the time a female is born. He thought that chromatin remodeling proteins did A lot of this work, by shifting spools all-around.
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Using the GCRLE grant, Munakata and Namekawa will look much more intently at how oocytes are genomically primed and saved for afterwards use. They'll examine the purpose of a chromatin remodeler in oocyte survival and fertility.
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Namekawa believes that in human oocytes, variations in these designs could disrupt the fragile choreography of genes currently being turned on and off at the proper periods — leaving them unprepared for fertilization or development into nutritious embryos. Adjustments in chromatin framework being an oocyte ages might also impression the best way that chromosomes segregate for the duration of mobile division.
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